KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
32.73
Human Site:
T323
Identified Species:
51.43
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
T323
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
T323
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
T323
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
Dog
Lupus familis
XP_543464
544
61233
T324
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
T327
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
Rat
Rattus norvegicus
NP_446129
545
60912
T326
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
T301
K
G
G
L
K
E
A
T
C
K
L
Y
F
Y
Q
Chicken
Gallus gallus
NP_001073576
522
58779
T300
P
V
K
M
K
E
A
T
C
K
L
Y
F
Y
Q
Frog
Xenopus laevis
NP_001082016
517
58243
I295
S
T
R
L
R
E
P
I
A
K
L
Y
F
Y
Q
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
N221
H
R
D
L
K
P
E
N
L
L
Y
Y
H
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
S276
I
I
S
N
K
L
L
S
E
D
I
S
K
L
Y
Honey Bee
Apis mellifera
XP_624334
480
54300
L279
L
I
F
Y
Q
V
V
L
A
V
S
Y
L
H
D
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
S276
N
R
M
G
L
G
E
S
L
G
K
Y
F
A
F
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
F279
E
A
T
A
K
F
Y
F
Y
Q
M
I
T
A
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
E304
K
T
C
L
R
Q
D
E
S
K
A
L
F
K
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
80
73.3
60
20
N.A.
6.6
6.6
20
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
80
86.6
73.3
33.3
N.A.
20
20
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
0
54
0
14
0
7
0
0
14
0
% A
% Cys:
0
0
7
0
0
0
0
0
54
0
0
0
0
0
7
% C
% Asp:
0
0
7
0
0
0
7
0
0
7
0
0
0
0
7
% D
% Glu:
7
0
0
0
0
60
14
7
7
0
0
0
0
0
0
% E
% Phe:
0
0
7
0
0
7
0
7
0
0
0
0
74
0
7
% F
% Gly:
0
7
7
7
0
7
0
0
0
7
0
0
0
0
7
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
7
7
0
% H
% Ile:
7
14
0
0
0
0
0
7
0
0
7
7
0
0
0
% I
% Lys:
14
40
7
0
74
0
0
0
0
67
7
0
7
7
0
% K
% Leu:
7
0
0
67
7
7
7
7
14
7
60
7
7
7
0
% L
% Met:
0
0
7
7
0
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
47
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
7
7
0
0
0
0
0
0
7
0
% P
% Gln:
0
0
0
0
7
7
0
0
0
7
0
0
0
0
67
% Q
% Arg:
0
14
47
0
14
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
7
0
7
0
0
0
0
14
7
0
7
7
0
0
0
% S
% Thr:
0
14
7
0
0
0
0
54
0
0
0
0
7
0
0
% T
% Val:
0
7
0
0
0
7
7
0
0
7
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
7
0
7
0
7
80
0
60
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _